Ipamorelin
5 mg
Selective ghrelin receptor agonist pentapeptide, 5 mg per vial.
- CAS
- 170851-70-4
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Storage
- Refrigerated
Comparison
Ipamorelin vs Hexarelin
Both act at the ghrelin receptor. One is the most selective compound in the GHRP family and the other is the most potent, and those two properties pull against each other.
What is the difference between ipamorelin and hexarelin?
Ipamorelin is the control compound precisely because it does so little else: minimal cortisol and prolactin involvement means ghrelin receptor activity can be studied in isolation. Hexarelin is more potent at that receptor but also binds cardiac CD36, so it is the right choice only when that second target is what the study is about, and the wrong one when it is a confound.
Side by side
| Property | Ipamorelin | Hexarelin |
|---|---|---|
| Length | Pentapeptide | Hexapeptide |
| Selectivity | Highest in the GHRP family | Lower; additional targets |
| Secondary targets | Minimal cortisol or prolactin activity | Binds cardiac CD36 |
| Molar mass | 711.86 g/mol | 887.0 g/mol |
| Potency at ghrelin receptor | Moderate | Highest in the classical GHRP family |
| Role in research | The clean control, isolating ghrelin receptor activity | Studied where the CD36 interaction is the point |
| Price | $46.00 · 5 mg | $52.00 · 5 mg |
Both compounds
Hexarelin
5 mg
Synthetic hexapeptide ghrelin receptor agonist, 5 mg per vial.
- CAS
- 140703-51-1
- Storage
- Refrigerated
Questions
Why is ipamorelin called selective?
It produces minimal activity at cortisol and prolactin pathways compared with the other growth hormone releasing peptides. That absence of secondary effects is what makes it the standard control in comparative work.
What is CD36 and why does it matter for hexarelin?
CD36 is a scavenger receptor expressed in cardiac tissue. Hexarelin binds it in addition to the ghrelin receptor, which gives it a second mechanism the other GHRPs do not have and makes it useful or confounding depending on the research question.
How do these differ from GHRH compounds?
GHRPs such as these act at the ghrelin receptor. GHRH analogues such as CJC-1295 and sermorelin act at the growth hormone releasing hormone receptor. They are the two separate arms of the same axis, which is why blends pairing one of each are common.
Other comparisons
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