Tirzepatide
10 mg
Dual GIP and GLP-1 receptor agonist, 10 mg per vial.
- CAS
- 2023788-19-2
- Storage
- Refrigerated
Comparison
Tirzepatide vs Retatrutide
The current frontier of incretin research: a dual agonist against a triple agonist. The added receptor is glucagon, and it changes what the compound is studied for rather than simply how much it does.
What is the difference between tirzepatide and retatrutide?
Tirzepatide is the established dual-agonist comparator with the larger body of published work behind it. Retatrutide is where the glucagon arm enters, which is a genuinely different mechanism rather than more of the same: appetite and glucose signalling are joined by energy expenditure. Because it is not approved anywhere, research supply is the only route to it, which is why demand is concentrated there right now.
Side by side
| Property | Tirzepatide | Retatrutide |
|---|---|---|
| Receptor targets | GIP and GLP-1 | GIP, GLP-1 and glucagon |
| Class | Dual agonist | Triple agonist |
| Added pathway | None beyond the two incretins | Glucagon receptor, recruiting energy expenditure |
| Molar mass | 4813.45 g/mol | 4731.35 g/mol |
| Regulatory status | Approved in major markets | Not approved in any market |
| Availability | Widely available | Research supply only |
| Price | $85.00 · 10 mg | $89.00 · 10 mg |
Both compounds
Retatrutide
10 mg
Triple GIP, GLP-1 and glucagon receptor agonist, 10 mg per vial.
- CAS
- 2381089-83-2
- Storage
- Refrigerated
Questions
What does the glucagon receptor add to a triple agonist?
Glucagon receptor activity recruits energy expenditure, a mechanism the two incretin receptors do not cover. That is what separates a triple agonist from a dual agonist rather than any difference in incretin potency.
Is retatrutide approved?
No. It is not approved in any market, and approval is not expected before 2027 at the earliest. Research supply is therefore the only route to the compound.
Why is retatrutide so heavily requested?
It is the newest molecule in the class, it adds a mechanism the others do not have, and it is unavailable through any approved channel. Those three together concentrate research demand on it.
Other comparisons
- BPC-157 vs TB-500 What is the difference between BPC-157 and TB-500?
- Semaglutide vs Tirzepatide What is the difference between semaglutide and tirzepatide?
- CJC-1295 with DAC vs without DAC What is the difference between CJC-1295 with and without DAC?
- IGF-1 LR3 vs IGF-1 DES What is the difference between IGF-1 LR3 and IGF-1 DES?
- Semax vs Selank What is the difference between Semax and Selank?
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