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Comparison

IGF-1 LR3 vs IGF-1 DES

Two modifications of insulin-like growth factor 1 that pull in opposite directions. Both reduce binding-protein affinity; one extends the exposure window dramatically, the other collapses it.

What is the difference between IGF-1 LR3 and IGF-1 DES?

The modifications answer two different research questions. LR3 is the one for sustained systemic exposure, because the extension and substitution together keep it circulating far longer than the native protein. DES is the one for a short, local signal, and the fact that both achieve their result by reducing binding-protein affinity is what makes the pair useful for isolating the role of those binding proteins.

Side by side

IGF-1 LR3 IGF-1 DES
Modification 13-residue N-terminal extension plus an Arg3 substitution First three N-terminal residues removed
Molar mass 9111 g/mol 7371 g/mol
Binding-protein affinity Sharply reduced Sharply reduced
Exposure Long, substantially beyond native IGF-1 Short and local
Studied for Sustained systemic IGF signalling Localised, time-limited signalling
Potency at receptor Comparable to native IGF-1 Reported higher than native IGF-1 in vitro
Price $46.00 · 1 mg $46.00 · 1 mg

Both compounds

IGF-1 LR3

1 mg

Long Arg3 analogue of insulin-like growth factor 1, 1 mg per vial.

Storage
Refrigerated

$46.00

In stock

IGF-1 DES

1 mg

Truncated IGF-1 lacking the first three residues, 1 mg per vial.

Storage
Refrigerated

$46.00

In stock

Questions

What does LR3 mean?

Long Arg3: a 13-amino-acid N-terminal extension combined with an arginine substitution at position three. Together they sharply reduce binding-protein affinity and extend circulating half-life.

What does DES stand for?

DES(1-3) refers to the removal of the first three N-terminal residues. The truncation reduces binding-protein affinity and produces a short, locally acting profile.

Which is closer to native IGF-1?

Neither. Both are engineered specifically to escape the binding proteins that regulate native IGF-1, which is the property the native molecule has and both variants deliberately lack.

Other comparisons

All products listed are sold strictly for in-vitro laboratory research and analytical use. They are not drugs, foods, cosmetics or medical devices, and are not intended to diagnose, treat, cure or prevent any disease.