Semaglutide
5 mg
Long-acting GLP-1 receptor agonist, lyophilised, 5 mg per vial.
- CAS
- 910463-68-2
- Storage
- Refrigerated
Comparison
Semaglutide vs Tirzepatide
The two most-searched compounds in metabolic research. The difference is not potency at a shared target, it is the number of receptors involved: one acts at a single incretin receptor, the other at two.
What is the difference between semaglutide and tirzepatide?
Semaglutide is the baseline: it isolates GLP-1 receptor activity, which is what makes it the control in nearly every incretin study. Tirzepatide adds GIP, so it is the compound to use when the research question is specifically what the second receptor contributes. Comparing them is how the GIP contribution gets measured at all.
Side by side
| Property | Semaglutide | Tirzepatide |
|---|---|---|
| Receptor targets | GLP-1 only | GIP and GLP-1 |
| Class | Single agonist | Dual agonist |
| Backbone | GLP-1 analogue, 31 residues | GIP-based sequence engineered for dual affinity |
| Molar mass | 4113.58 g/mol | 4813.45 g/mol |
| Half-life strategy | C18 fatty diacid chain, albumin binding | C20 fatty diacid chain, albumin binding |
| Role in research | The reference incretin comparator | The dual-agonist comparator |
| Price | $55.00 · 5 mg | $85.00 · 10 mg |
Both compounds
Tirzepatide
10 mg
Dual GIP and GLP-1 receptor agonist, 10 mg per vial.
- CAS
- 2023788-19-2
- Storage
- Refrigerated
Questions
Is tirzepatide just a stronger semaglutide?
No. It acts at an additional receptor. Tirzepatide is a dual GIP and GLP-1 agonist, while semaglutide acts at GLP-1 alone, so the difference is mechanistic rather than a matter of relative strength at one shared target.
What does GIP add?
GIP is the other major incretin hormone. Recruiting it alongside GLP-1 produced larger effects in metabolic models than GLP-1 agonism on its own, and isolating that contribution is the reason the two compounds are studied against each other.
Which came first?
Semaglutide. It established the long-acting GLP-1 analogue as the reference compound, and the dual and triple agonists were developed afterwards against that benchmark.
Other comparisons
- BPC-157 vs TB-500 What is the difference between BPC-157 and TB-500?
- Tirzepatide vs Retatrutide What is the difference between tirzepatide and retatrutide?
- CJC-1295 with DAC vs without DAC What is the difference between CJC-1295 with and without DAC?
- IGF-1 LR3 vs IGF-1 DES What is the difference between IGF-1 LR3 and IGF-1 DES?
- Semax vs Selank What is the difference between Semax and Selank?
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