Epithalon
50 mg
Tetrapeptide pineal bioregulator, 50 mg per vial.
- Sequence
- AEDG
- Storage
- Refrigerated
Comparison
Epithalon vs MOTS-c
The two most-requested compounds in longevity research, arrived at from completely different directions: one from pineal gland extract work, the other from reading the mitochondrial genome.
What is the difference between epithalon and MOTS-c?
They address longevity from opposite ends. Epithalon belongs to the bioregulator tradition and is studied for telomerase and circadian endpoints. MOTS-c is a mitochondrial-derived peptide studied for metabolic signalling, and is as much a metabolic compound as a longevity one. Researchers running both are usually covering two distinct hypotheses rather than reinforcing one.
Side by side
| Property | Epithalon | MOTS-c |
|---|---|---|
| Origin | Developed from pineal gland extract research | Encoded in mitochondrial DNA |
| Length | Tetrapeptide, AEDG | 16 residues, MRWQEMGYIFYPRKLR |
| Molar mass | 390.3 g/mol | 2174.6 g/mol |
| Primary pathway studied | Telomerase expression, circadian regulation | AMPK signalling, glucose handling |
| Research domain | Senescence and telomere biology | Metabolic and exercise-response models |
| Compound family | Khavinson bioregulator series | Mitochondrial-derived peptides |
| Price | $82.00 · 50 mg | $76.00 · 10 mg |
Both compounds
MOTS-c
10 mg
Mitochondria-derived 16-amino-acid peptide, 10 mg per vial.
- Sequence
- MRWQEMGYIFYPRKLR
- Storage
- Refrigerated
Questions
What makes MOTS-c unusual?
It is encoded in mitochondrial DNA rather than nuclear DNA, which made it one of the first identified mitochondrial-derived peptides and opened a category that now includes humanin and others.
What is the Khavinson series?
A family of very short peptide bioregulators, typically two to four residues, each associated with a specific tissue type. Epithalon is the pineal member and the most widely studied of them.
Are they studied together?
Often, because their mechanisms do not overlap. One targets telomere and circadian endpoints, the other metabolic signalling, so a combined protocol tests two independent hypotheses rather than one.
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